The Houston Chronicle is reporting that Sean O'Keefe may be leaving NASA for LSU:

After three tumultuous years at the space agency's helm, NASA administrator Sean O'Keefe is poised to leave the Bush administration to become chancellor of Louisiana State University in Baton Rouge.

An announcement could come as early as Monday, officials familiar with the situation said today.

O'Keefe formally applied for the $500,000 a year post late Friday after heavy recruiting by the university to land him...

O'Keefe would not comment Saturday and the White House did not respond to queries Saturday.